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human mat2a  (Addgene inc)


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    Structured Review

    Addgene inc human mat2a
    Summary of V/K Kinetic Isotope Effects, Intrinsic Kinetic Isotope Effects, Binding Isotope Effects and Calculated Kinetic Isotope Effects from QM Calculations for <t> Human MAT2A </t> at 5 Atomic Positions
    Human Mat2a, supplied by Addgene inc, used in various techniques. Bioz Stars score: 92/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human mat2a/product/Addgene inc
    Average 92 stars, based on 5 article reviews
    human mat2a - by Bioz Stars, 2026-05
    92/100 stars

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    1) Product Images from "The Transition-State Structure for Human MAT2A from Isotope Effects"

    Article Title: The Transition-State Structure for Human MAT2A from Isotope Effects

    Journal: Journal of the American Chemical Society

    doi: 10.1021/jacs.7b05803

    Summary of V/K Kinetic Isotope Effects, Intrinsic Kinetic Isotope Effects, Binding Isotope Effects and Calculated Kinetic Isotope Effects from QM Calculations for Human MAT2A at 5 Atomic Positions
    Figure Legend Snippet: Summary of V/K Kinetic Isotope Effects, Intrinsic Kinetic Isotope Effects, Binding Isotope Effects and Calculated Kinetic Isotope Effects from QM Calculations for Human MAT2A at 5 Atomic Positions

    Techniques Used: Binding Assay

    MAT2A catalyzes the formation of SAM from ATP and methionine. KIE measurements used isotopically labeled substrates with the labels indicated. Each color corresponds to labels found on an individual substrate molecule.
    Figure Legend Snippet: MAT2A catalyzes the formation of SAM from ATP and methionine. KIE measurements used isotopically labeled substrates with the labels indicated. Each color corresponds to labels found on an individual substrate molecule.

    Techniques Used: Labeling

    (A) Geometric and electrostatic potential surface (EPS) maps for the MAT2A transition state. Red color designates partial negative charge while blue color designates partial positive charge. (B) Zoomed in EPS maps of the central sulfur atom for the MAT2A transition state (TS), S-adenosyl-L-methionine (SAM) and methionine (Met) are shown for comparison. The partial positive charge on the sulfonium group is significantly reduced in the transition state structure when compared to the SAM structure.
    Figure Legend Snippet: (A) Geometric and electrostatic potential surface (EPS) maps for the MAT2A transition state. Red color designates partial negative charge while blue color designates partial positive charge. (B) Zoomed in EPS maps of the central sulfur atom for the MAT2A transition state (TS), S-adenosyl-L-methionine (SAM) and methionine (Met) are shown for comparison. The partial positive charge on the sulfonium group is significantly reduced in the transition state structure when compared to the SAM structure.

    Techniques Used: Comparison



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    Image Search Results


    Summary of V/K Kinetic Isotope Effects, Intrinsic Kinetic Isotope Effects, Binding Isotope Effects and Calculated Kinetic Isotope Effects from QM Calculations for Human MAT2A at 5 Atomic Positions

    Journal: Journal of the American Chemical Society

    Article Title: The Transition-State Structure for Human MAT2A from Isotope Effects

    doi: 10.1021/jacs.7b05803

    Figure Lengend Snippet: Summary of V/K Kinetic Isotope Effects, Intrinsic Kinetic Isotope Effects, Binding Isotope Effects and Calculated Kinetic Isotope Effects from QM Calculations for Human MAT2A at 5 Atomic Positions

    Article Snippet: A synthetic plasmid encoding human MAT2A was designed in a modified pET vector (now deposited at AddGene).

    Techniques: Binding Assay

    MAT2A catalyzes the formation of SAM from ATP and methionine. KIE measurements used isotopically labeled substrates with the labels indicated. Each color corresponds to labels found on an individual substrate molecule.

    Journal: Journal of the American Chemical Society

    Article Title: The Transition-State Structure for Human MAT2A from Isotope Effects

    doi: 10.1021/jacs.7b05803

    Figure Lengend Snippet: MAT2A catalyzes the formation of SAM from ATP and methionine. KIE measurements used isotopically labeled substrates with the labels indicated. Each color corresponds to labels found on an individual substrate molecule.

    Article Snippet: A synthetic plasmid encoding human MAT2A was designed in a modified pET vector (now deposited at AddGene).

    Techniques: Labeling

    (A) Geometric and electrostatic potential surface (EPS) maps for the MAT2A transition state. Red color designates partial negative charge while blue color designates partial positive charge. (B) Zoomed in EPS maps of the central sulfur atom for the MAT2A transition state (TS), S-adenosyl-L-methionine (SAM) and methionine (Met) are shown for comparison. The partial positive charge on the sulfonium group is significantly reduced in the transition state structure when compared to the SAM structure.

    Journal: Journal of the American Chemical Society

    Article Title: The Transition-State Structure for Human MAT2A from Isotope Effects

    doi: 10.1021/jacs.7b05803

    Figure Lengend Snippet: (A) Geometric and electrostatic potential surface (EPS) maps for the MAT2A transition state. Red color designates partial negative charge while blue color designates partial positive charge. (B) Zoomed in EPS maps of the central sulfur atom for the MAT2A transition state (TS), S-adenosyl-L-methionine (SAM) and methionine (Met) are shown for comparison. The partial positive charge on the sulfonium group is significantly reduced in the transition state structure when compared to the SAM structure.

    Article Snippet: A synthetic plasmid encoding human MAT2A was designed in a modified pET vector (now deposited at AddGene).

    Techniques: Comparison

    Proteins significantly regulated following RAPTA-T treatment determined from FITExP analysis of MCF-7 and MDA-MB-231 cells.

    Journal: Scientific Reports

    Article Title: Expression proteomics study to determine metallodrug targets and optimal drug combinations

    doi: 10.1038/s41598-017-01643-1

    Figure Lengend Snippet: Proteins significantly regulated following RAPTA-T treatment determined from FITExP analysis of MCF-7 and MDA-MB-231 cells.

    Article Snippet: Human MAT2A plasmid was obtained from Addgene ( www.addgene.org , plasmid #53648) as a bacterial stab.

    Techniques: Transmission Assay